The nature of cryptic epitopes within the self-antigen myelin basic protein
نویسندگان
چکیده
منابع مشابه
heterogeneity within the orientalist discourse: representation of the orient in womens travelogues and mens paintings
from 1950s onward, new theories and critical approaches burgeoned across humanities. these theories were context-oriented; as a result, the analysis of discursive practices gained significance. thus, social, political, historical and cultural discourses that have been hitherto marginalized and considered inferior to literary texts, were introduced as important texts to be analyzed by critics. o...
Presentation of the self antigen myelin basic protein by dendritic cells leads to experimental autoimmune encephalomyelitis.
Bone marrow (BM)-derived dendritic cells (DC) are potent stimulators of naive CD4+ T cell activation. Because DC are efficient at Ag processing and could potentially present self Ags, we investigated the role of DC in the presentation of an encephalitogenic peptide from myelin basic protein (Ac1-11) in the induction of experimental autoimmune encephalomyelitis (EAE). To determine if DC could pr...
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Objective: Multiple sclerosis (MS) is presented with motor and sensory function loss. It is caused by demyelination and following axonal lesion. As myelin basic protein (MBP) is one of the key elements of the myelin cover, we examined the level of MBP in serum, stimulated, and unstimulated saliva as a suitable biomarker for detecting MS. Methods: A case-control study was performed in 29 health...
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The fact that central nerve tissue is encephalitogenic has been known since the observation of a post-injection reaction of some rabies victims to the Pasteur vaccine that contained nerve tissue (Brostoff, 1977). Subsequently the encephalitogenic agent in central nerve tissue was traced to a component of the myelin sheath, and a protein was finally isolated that in the presence of complete Freu...
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ژورنال
عنوان ژورنال: International Immunology
سال: 1996
ISSN: 0953-8178,1460-2377
DOI: 10.1093/intimm/8.7.1035